Among them, cytokines derived from adipocyte, such as leptin, globular adiponectin, resistin, IGFBP-2, and CCL5, can be used as paracrine signals of cancer cells to upregulate invasion related proteins such as calcium binding protein S100A7, MMP-9, and urokinase type plasmin activator (UPA), thereby promoting the invasion and migration of cancer cells [208–210]. The gene discussed is IGFBP2; the disease is cancer.