USP7 and cancer: For example, chemotherapy drugs CDDP and paclitaxel inhibit arachidonate lipoxygenase by activating the Ubiquitin Specific Peptidase 7 (USP7)/heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) axis 15 (ALOX15) and reduce the accumulation of lipid-reactive oxygen species (ROS) in cancer cells and ultimately lead to a decrease in chemotherapy sensitivity [98].