In addition, adipocytes can also support tumor progression by regulating immune cells in TME, such as the levels of exosome microRNA (miRNA)-155 increased during co-culture of tumor cells and adipocytes, thereby recruiting macrophages and promoting their differentiation into TAMs that support tumor development [220–222] In addition, visfatin secreted by CAAs can also induce M2 macrophage polarization and accelerate the glycolysis process in malignant tumor cells [223]. This evidence concerns the gene NAMPT and neoplasm.