CXCR4 and neoplasm: In order to improve the tumor homing characteristics of MSCs, the P-selectin ligand PSGL-1 mRNA, E-/L-selectin ligand SLeX mRNA, or CXCR4 mRNA were transfected into MSCs, resulting in the rolling and adhesion of the modified MSCs in vascular endothelial cells was enhanced, thereby increasing the homing of MSCs [144].