At the same time, co-culture of mature adipocytes and breast cancer cells can promote cancer cell growth [200] and mediate EMT by enhancing the expression of MCF7 cell Forkhead Box C2 (FOXC2), twist family bHLH transcription factor 1 (TWIST1), and N- and E-cadherin [201]. This evidence concerns the gene TWIST1 and breast carcinoma.