In addition, the single-cell RNA sequencing of stromal cells in human tumor samples showed that the CAFs subgroup had different transcriptional profiles, the first is mycofabric CAFs which are characterized by high expression of α-SMA and are located near tumor cell nests, followed by iCAFs which are located in fibroproliferative regions away from tumor cells and characterized by low expression of α-SMA and highly expression of IL-6, Leukemia Inhibitory Factor (LIF), IL-11, CXCL1, CXCL8 and platelet-derived growth factor receptor (PDGFR)-α [37]. Here, LIF is linked to neoplasm.