Previous studies have shown that ABTL0812 induces AKT-MRORC1 inhibition and autophagy-mediated tumor cell death by promoting the expression of TRIB3, a pseudokinase that binds and prevents AKT activation by upstream kinases PDPK1 and MTORC2 [107, 109]. The gene discussed is AKT1; the disease is neoplasm.