CRTC3 and hepatocellular carcinoma: To specify the types of cell death, we used a ferroptosis inhibitor (Ferrostatin-1) and found that CRTC3-KO and CRTC3-WT HCC cell death upon RSL3 treatment were markedly inhibited by Ferrostatin-1, and the inhibitory degree was much higher in the CRTC3-KO group (Fig. 4f).