A prior study revealed that RAE-1ε, a protein expressed by lymph node endothelial cells (LNECs) and strongly expressed by TECs, activates NKG2D, causing internalization of NKG2D from the NK cell surface and transmitting an NK-intrinsic signal that desensitizes NK cells function, ultimately leading to impaired anti-tumor effects in vivo [113]. Here, KLRK1 is linked to neoplasm.