In murine models, tumor-associated high endothelial venule ECs (TA-HECs) derived from post-capillary venules are recruited into tumors and associated with different types of T cells; enhancement of TA-HECs leads to higher proportions of anti-tumor stem-like CD8+ T cells and improves the effectiveness of immune checkpoint blockade (ICB) [80]. This evidence concerns the gene CD8A and neoplasm.