TFRC and colorectal carcinoma: These results suggest that induction of autophagy partially restored TFRC degradation in HT29-shANXA10 cells, implying that knockdown of ANXA10 prevented TFRC degradation by inhibiting the autophagic process, especially the degradation of TFRC in the lysosome, thereby inducing ferroptosis in CRC cells (Fig. 6G).