Pre-clinical mouse studies have shown that cDC1s (type I conventional dendritic cells) in tumor-draining LNs (tdLNs) maintain a reservoir of proliferative tumor-reactive Tpex and that boosting cDC1s increases Tpex cell frequencies and decreases tumor burden.2 Rahim et al. show that neoadjuvant ICB decreased frequencies of Tpex cells and increased frequencies of Tex-int in uiLNs and altered the spatial organization of the uiLNs increasing the numbers of neighboring DCs of both Tpex and Tex-int cells. The gene discussed is TEX46; the disease is neoplasm.