KRAS and non-small cell lung carcinoma: Although previous studies have reported the roles of K-Ras signaling on regulating redox balance, our study reveals direct effects of the redox balance on K-Ras/PM binding and its signal output, thus providing a mechanistic link between K-Ras and recent reports on the antioxidant-induced growth and metastasis of K-Ras-driven NSCLC (Sayin et al, 2014; Lignitto et al, 2019; Wiel et al, 2019).