KEAP1 and non-small cell lung carcinoma: Consistently, promoting the endogenous antioxidant program either by activating NRF2 (nuclear factor erythroid-derived 2-like 2), the master transcriptional regulator of antioxidant responses, or blocking its negative regulator, KEAP1 (Kelch-like ECH-associated protein 1), up-regulates heme oxygenease-1, which degrade free heme, resulting in the BACH1-dependent metastasis of K-Ras-driven NSCLC (Li & Stocker, 2009; Wiel et al, 2019).