KRAS and cancer: Depletion of PM PtdSer by perturbing mechanisms that maintain PM PtdSer abundance dissociates K-Ras from the PM and blocks K-Ras signal output and the growth of human cancers harboring oncogenic mutant K-Ras in vitro and in vivo (Cho et al, 2012b, 2016b; van der Hoeven et al, 2018; Kattan et al, 2021).