BRAF and astrocytoma (excluding glioblastoma): This would make plausible biological sense, given TERT mutation status can be mutant or wildtype across the glioblastomas, mutant in oligodendroglioma and typically wildtype in astrocytoma, therefore the range of possible TERT alterations cover a large proportion of tumour diagnoses.27,83,84,100,101 In addition, BRAF alterations are essentially indicative of a set of specific tumour diagnoses,27,81,105-110 with relatively little scope for mutation amongst other diagnoses.