Lastly, while ATRX loss was confirmed to be associated with preservation of 1p/19q, isolated 19q deletion was found to occasionally exist with ATRX loss in 19q-deleted astrocytoma.98 Both histone G34R and K27M mutants could manifest ATRX loss or retention. The gene discussed is ATRX; the disease is astrocytoma (excluding glioblastoma).