FOLR1 and ovarian serous adenocarcinoma: As folate is necessary for DNA synthesis and cellular proliferation, FRα is upregulated when cellular metabolic demand increases, that is typical of cancer cells.97,98 FRα is overexpressed in different cancers, especially high-grade serous ovarian cancer (OC), and its expression remains constant without being influenced by systemic therapies, thus representing an ideal therapeutic target.99