These MVBs export as exosomes to reduce intracellular iron concentration, thereby alleviating cell ferroptosis.7,8 PROM2 is activated by p38-mediated HSF1 transcription to antaonized 4HNE or RSL3-induced ferroptosis.9 Notably, PROM2 can promote gemcitabine resistance by activating Akt signaling pathway in pancreatic cancer.10 However, the role and mechanism of PROM2 in NSCLC remains unclear. This evidence concerns the gene PROM2 and non-small cell lung carcinoma.