AKT1 and non-small cell lung carcinoma: These MVBs export as exosomes to reduce intracellular iron concentration, thereby alleviating cell ferroptosis.7,8 PROM2 is activated by p38-mediated HSF1 transcription to antaonized 4HNE or RSL3-induced ferroptosis.9 Notably, PROM2 can promote gemcitabine resistance by activating Akt signaling pathway in pancreatic cancer.10 However, the role and mechanism of PROM2 in NSCLC remains unclear.