It has been reported that the increases in cell invasion and migration abilities may be a consequence of cisplatin resistance, resulting in enhanced cancer metastasis after long-term treatment with cisplatin.30 Therefore, we suspected that up-regulation of CTCF/PROM2 decreases cisplatin sensitivity and then enhances NSCLC cell migration and invasion. The gene discussed is CTCF; the disease is non-small cell lung carcinoma.