Besides, reporters have confirmed that cisplatin resistance in NSCLC can result from alterations in regulation of the cell apoptosis.27 Based on the results that high expression of PROM2 promoted the proliferation, migration and invasion, we hypothesized that PROM2 can decrease cisplatin sensitivity via enhancing NSCLC cells survival and metastasis, thereby promoting cisplatin resistance. Here, PROM2 is linked to non-small cell lung carcinoma.