Nowadays, the complexity of the tumor microenvironment is increasingly emphasized because it abounds with various pro-angiogenic factors such as vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and platelet-derived growth factor (PDGF).3 Angiogenesis is crucial for tumor growth, maintenance, and metastasis.4 The concept of antiangiogenic therapy is evolving and gaining attention due to its essential role in tumor development. The gene discussed is FGF2; the disease is neoplasm.