ABCA7 and Alzheimer disease: Notably, rs3829687 located in the previously established AD gene ABCA7 showed mild association upon analysis of the clinically diagnosed AD cases and controls (P=6.4×10-6) and in the analysis with the newly classified subjects (P=3.5×10-7) using the IP method but was marginal (P=8.9×10-8) using the WIP method (Supplementary Fig. S5B).