To evaluate the predictive value of 12 CRGs (ATP7B, CDKN2A, DLAT, DLD, FDX1, GLS, LIAS, LIPT1, MTF1, PDHA1, PDHB, SLC31A1) for clinical outcomes in the TCGA-ESCC dataset, we used the transcriptome expression matrix of 79 patients with ESCC who had a survival time greater than zero to construct a prognosis signature through the LASSO algorithm (Figure 6A, 6B). Here, CDKN2A is linked to esophageal squamous cell carcinoma.