To investigate somatic mutations in 12 CRGs (ATP7B, CDKN2A, DLAT, DLD, FDX1, GLS, LIAS, LIPT1, MTF1, PDHA1, PDHB, SLC31A1) in ESCC from the TCGA-ESCC cohort, we summarized the results of genetic mutation analysis. Here, CDKN2A is linked to esophageal squamous cell carcinoma.