No evidence of infiltration was observed in WT, PRL2-KO, or PRL2-KO;PTEN HET mice, whereas severe leukemia blast infiltration throughout the liver tissue was detected in some PTEN HET mice.The detailed lymphoid analyses indicate that the majority of the PTEN HET animals in this model system are experiencing a severe AML-specific disease phenotype, with a minimally occurring population only possessing ALL characteristics instead. This evidence concerns the gene PTEN and acute lymphoblastic leukemia.