The PTEN HET mice exhibited an overall AML phenotype comparable with previously established transgenic AML models: stem cell morphology reflected a reduction in normal HSCs, there was a general shift in MPP cell populations toward GMP lineages, there was an accumulation of clinically relevant (>20%) concentrations of blast-like cells within the BM, and there was infiltration of these blast-like cells to distal tissues such as the spleen (46). This evidence concerns the gene PTEN and acute myeloid leukemia.