The conditional animal model exhibiting an AML phenotype was generated by cross-breeding mice possessing PTEN-floxed alleles with mice carrying the conditionally activated Rosa26-Cre-ERT2 promoter to obtain Rosa26Cre/Cre WT and the inducible Rosa26Cre/Cre;PTENwt/fl PTEN heterozygous (PTEN HET) mice. Here, MAPK3 is linked to acute myeloid leukemia.