Of the 60 patients who did not receive any medical treatment for acromegaly at five-year, the median IGF-1/ULN was 0.8 (0.6–0.9, range: 0.2–1.3) and median GH was 0.5 (0.2–1.3) μg/L. The gene discussed is IGF1; the disease is acromegaly.