We next analyzed the contribution of the RAGE AA 362–367 mutation to RIPK1 phosphorylation and found that hyperglycemia‐induced RIPK1 phosphorylation was dramatically lower with mutated RAGE than with wild‐type RAGE (F(5, 18) = 161.70, db/db + RAGE‐KD + Wt vs db/db + RAGE‐KD, p < 0.001; db/db + RAGE‐KD + Mut vs db/db + RAGE‐KD + Wt, p < 0.001; Figure 5D1,D2). Here, AGER is linked to Hyperglycemia.