In the NOR test, hyperglycemia induced cognitive decline, as indicated by a decrease in DI in db/db mice, but this decline was not present in db/db knockdown mice treated with mutant RAGE (F(5, 42) = 7.98, db/db vs db/m, p = 0.002; db/db + RAGE‐KD vs db/db, p = 0.006; db/db + RAGE‐KD + Wt vs db/db + RAGE‐KD, p = 0.008; db/db + RAGE‐KD + Mut vs db/db + RAGE‐KD + Wt, p = 0.02; Figure 6C). Here, AGER is linked to Mental deterioration.