For example, two lipid phosphatases – INPP5E, which is among the genes mutated in the ciliopathy Joubert syndrome, and OCRL1, mutated in the ciliopathy-like Lowe syndrome – have been reported to be important both for primary ciliogenesis (Hardee et al., 2017; Luo et al., 2012a,b; Xu et al., 2017) and for autophagosome–lysosome fusion (De Leo et al., 2016; Hasegawa et al., 2016). The gene discussed is INPP5E; the disease is Joubert syndrome.