Moreover, given that Rab19 targeting to the site of ciliogenesis was also disrupted when autophagy initiation was blocked (Fig. S3E), it would be worth investigating the role of Rab19 in disorders where ciliary defects are associated with abnormal autophagy, including polycystic kidney disease (Morleo and Franco, 2019; Wang and Dong, 2020; Zhu et al., 2016) and focal cortical dyslamination (Morleo and Franco, 2019; Park et al., 2018). Here, RAB19 is linked to polycystic kidney disease.