NEFL and Spinocerebellar ataxia type 3: Although these mice showed no correlation between age and serum NfL, this result is consistent with studies on patients with SCA3 demonstrating decreased magnitude of blood NfL increases over time (Li et al., 2019; Peng et al., 2022; Wilke et al., 2020b; Faber et al., 2023 preprint).