NEFL and Spinocerebellar ataxia type 3: The present study demonstrates that YACQ84 mice broadly mirror some of the main trends in blood NfL in patients with SCA3, specifically that aged homozygous YACQ84 transgenic mice show increased levels of blood NfL compared to those of non-diseased controls, which correlate with neurochemical signs of cerebellar damage (McLoughlin et al., 2023).