(178) found that among subjects with diabetes periodontitis, macrophages stimulated by high glucose would lead to insufficient secretion of SIRT6 and induce disorder of SIRT6-miR-216/217 axis, accompanied by neutrophil apoptosis, impeded efferocytosis, and increased neutrophil extracellular traps, thus aggravating the inflammatory response of periodontitis. This evidence concerns the gene SIRT6 and diabetes mellitus.