In addition, miR-223 is correlated with proinflammatory cytokines TNF-α, anti-inflammatory cytokines TGF-β and IL-10, and periodontitis clinical parameters such as probing depth (PD) and clinical attachment loss (CAL) in varying degrees; it is also highly correlated with susceptibility to diabetes mellitus and glycemic control levels (134). This evidence concerns the gene TNF and periodontitis.