KEGG enrichment analysis of 401 DEGs related to the mechanism of ovariectomized osteoporosis in the NE/Ovx group showed that Cytokine-cytokine receptor interaction, osteoclast differentiation, PI3K-Akt signaling pathway, Focal adhesion, Wnt signaling pathway, TGF-beta signaling pathway, Neuroactive ligand-receptor interaction, Parathyroid hormone synthesis, secretion and action, ECM-receptor interaction, and Hippo signaling pathway were significantly enriched. This evidence concerns the gene PTH and osteoporosis.