TNF and osteoporosis: Meanwhile, the KEGG enrichment analysis of 213 DEGs related to the improvement mechanism of ovariectomized osteoporosis in the RE/Ovx group showed that RE was mainly enriched with the Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Osteoclast differentiation, AMPK signaling pathway, TGF-beta signaling pathway, Hippo signaling pathway, TNF signaling pathway (Figure 7B).