(33) found accelerated tumor accretion and significantly higher number of tumor cells in GPX3-deficient COAD mice, which also exhibited macrophage tendency to M2 polarization, enhanced expression of inflammatory factors, and over-activation of WNT signaling pathway.GPX3 in COAD mice exhibited immunomodulatory effects limiting the development of enteritis-associated cancers. The gene discussed is GPX3; the disease is cancer.