(28) demonstrated through In-vitro assays that CALB2 silencing inhibits ovarian high-grade plasmacytoma (HGSC) cell adhesion, which in turn caused peritoneal spread, and notably, that high CALB2 expression contributed to poor prognosis of HGSC.GEM was primarily subject to enzymatic deamination, low clearance, and drug resistance and It was currently intended primarily as alternative second-line therapeutic agent to 5-FU for the treatment of multiple cancers (4). The gene discussed is CALB2; the disease is plasmacytoma.