PRKACA and hypertensive disorder: Figure 3 illustrates the Ilex kudingcha–ingredient–target–hypertension regulatory network. The active ingredients kaempferol and quercetin were associated with 42 and 111 target genes, respectively. Therefore, they were classified as multitarget and multieffect compounds. The genes PTGS1, PTGS2, PRKACA, and PPARG were associated with the highest number of active components.