KEGG enrichment analysis revealed that the antihypertensive mechanism of Ilex kudingcha was mainly concentrated in lipid and atherosclerosis, fluid shear stress and atherosclerosis, the AGE-RAGE signaling pathway in diabetic complications, human cytomegalovirus infection, the TNF signaling pathway, chemical carcinogenesis receptor activation, hepatitis B, prostate cancer, and Chagas disease (Figure 7). Here, TNF is linked to Chagas disease.