Although the number of CD4+CD25+CD127lo cells in Ccl21a-KO dLNs was significantly lower than that of WT dLNs without tumors (Supplementary Fig. 3A, Fig. 6A), the number increased more significantly in Ccl21a-KO dLNs (approximately 6-fold) compared with the WT dLNs (approximately 1.7-fold) as the tumor grew. This evidence concerns the gene CD4 and neoplasm.