(i) mNIS expression can be detected by SPECT (with [99mTc]pertechnetate) [18] or PET (with [18F]TFB) [19] and as endogenous levels of NIS expression are extremely low or absent in most organs of the adult mouse (notable exceptions being the salivary glands, thyroid, lactating breast and stomach [35]), it offers very high image contrast of tumor lesions relative to normal tissue at most body locations. The gene discussed is SLC5A5; the disease is neoplasm.