TLR1 and Autoimmunity: The TLR1 locus that colocalized with risk loci for BrCa (rs6815814, p = 6.13−13) and autoimmunity (rs5743618, p = 4−114)41 was also in LD (r2 > 0.6) with multiple fSNPs predicted to disrupt transcriptional regulatory regions (rs5743565 and rs11722889) (Figure 5D) and multiple eSNPs that correlated with expression across various human leukocyte cell types (Figures 5E–5H).