CTCF and neurodevelopmental disorder: While only three de novo CTCF disease-causing variants (c.615_618delGAAA[p.Lys206Profs15], c.1699C>T[p.Arg567Trp], c.329dupT[p.Gly111fs29) have been identified in Chinese patients associated with the neurodevelopmental disorder, there is an urgent need to report additional genetic and clinical features from Chinese ID patients to expand the spectrum of CTCF variation in the Chinese population (11).