COX15 and neurodevelopmental disorder: Among the 507 DEGs, 194 were down-regulated and 313 were up-regulated consistently and shared between the two patients, including several genes associated with neurodevelopmental disorders such as CAMKMT. Relative quantification of a subset of genes (CAMKMT, COX15, and GAS7) using RT-qPCR confirmed the accuracy of differential analysis with RNA-seq data (Figure 3B).