Further, it was demonstrated that GSDMD triggered the expression of proinflammatory cytokines (such as IL-1β, TNF-α, and MCP-1), resulting in the activation of the NF-κB signaling pathway and the subsequent recruitment of macrophages in MASH, implying that the pyroptosis-GSDMD axis plays a crucial role in the development of MASH. The gene discussed is IL1B; the disease is metabolic dysfunction-associated steatohepatitis.