In the setting of diet-induced liver inflammation and fibrosis, levels of inflammasome components, including NLRP3, pro-IL-18, pro-IL-1β, ASC, and caspase-1 were found to be elevated in both MASH patients and experimental MASH animal models (Wree et al., 2014b; Gaul et al., 2021). This evidence concerns the gene CASP1 and metabolic dysfunction-associated steatohepatitis.