IL1B and gastric cancer: Besides cell death, GSDME activation leads to the production and secretion of IL-1α and IL-1β from macrophages, IL-1β from neutrophils, HMGB1 from intraepithelial cells, and IL-18 from gastric cancer cell lines (Aizawa et al., 2020; Tan et al., 2020; Huang J. et al., 2021a; Chen et al., 2021; Zhou and Abbott, 2021).