Indeed, Henao-Mejia et al. (2012) found that in models of isolated hepatic steatosis, including a short-term (4 weeks) methionine and choline-deficient diet (MCD) diet model, various global inflammasome-related knockouts (Asc−/−, Caspase-1−/−, Il-18−/−, Nlrp6−/−, Nlrp3−/−, Nlrc4−/−) had increased levels of ALT and AST as well as increased MASLD activity scores, with similar results in the leptin-receptor deficient animals (db/db) MASLD mouse model which was additionally co-housed with Asc−/− mice resulting in comparable levels of liver injury. The gene discussed is NLRP3; the disease is fatty liver disease.