Loss of GSDMD expression rescues mice with a D301N Nlrp3 mutation causing the Neonatal-onset multisystem inflammatory disease (NOMID) as well as mice with a neutrophil-specific A350V Nlrp3 mutation, which is associated with Muckle-Wells Syndrome (Xiao et al., 2018; Kaufmann et al., 2022a). This evidence concerns the gene NLRP3 and Muckle-Wells syndrome.