The soluble form of the regulatory IL-1 decoy receptor, sIL-1R2, which was markedly higher in our PD patients, was shown to be upregulated in several inflammatory chronic diseases such as multiple sclerosis, rheumatoid arthritis, and AD, acting as an inflammatory biomarker (Molgora et al., 2018; Supino et al., 2022). The gene discussed is IL1R2; the disease is rheumatoid arthritis.