IL-1 also negatively affects neuronal survival (Liu and Quan, 2018) and plays a crucial role in neurodegenerative processes, including PD, Alzheimer’s disease (AD), acute brain injury, central nervous system (CNS) autoimmunity, post-infectious neuropathology, and febrile convulsions (Khazim et al., 2018; Liu and Quan, 2018; Mantovani et al., 2019). Here, IL1B is linked to Alzheimer disease.