The main findings of the present study are that 1) patients with PD had higher sIL-1R2 plasma concentration than age- and sex-matched healthy subjects; 2) in PD patients, higher sympathetic and lower parasympathetic modulatory activities to the heart, as assessed by the spectral markers of RR variability, were associated with higher plasma levels of sIL-1R2, and 3) changes in the spectral indices of cardiac autonomic control, elicited by repetitive AMPSS, were related to changes in the levels of sIL-1R2. Here, IL1R2 is linked to Parkinson disease.