Depends on the source of microbiome:  From Lactobacillus acidophilus and Lactobacillus casei can reduce the secretion of (TNF-α) and increase the secretion of IL-10 [18].  - From Lactobacillus casei and Lactobacillus rhamnosus can prevent the invasion of colon cancer cells. - From Lactobacillus and Bifidobacterium can prevent the invasion of enteroinvasive Escherichia coli, which can help with diarrhea. - From Lactobacillus plantarum has a positive effect on the intestinal barrier and decreases TNF-α and IL-1β. The gene discussed is IL1B; the disease is colonic neoplasm.