In contrast, the ones derived from Lactobacillus casei and Lactobacillus rhamnosus can prevent the invasion of colon cancer cells, and the ones derived from Lactobacillus and Bifidobacterium can prevent the invasion of enteroinvasive Escherichia coli, which can help in diarrhea, and Lactobacillus plantarum has a positive effect on intestinal barrier and decreases TNF-α and IL-1β. Here, TNF is linked to colonic neoplasm.