NFKB1 and metabolic dysfunction-associated steatohepatitis: 1. LPS deteriorates NASH progression. 2. Induces hepatic inflammatory response and fibrosis via LPS/TLR4 and NFkB signaling pathways in hepatocytes, HSCs, and Kupfer cells. 3. Activates CD14-TLR4 promoting the release of inflammatory cytokines (NF-kB). 4. Induces the activation of macrophages and platelets through the TLR4 pathway, thereby eliciting liver damage. 5. Promotes the expression of TGF-β, which induces the transcription of certain pathways promoting hepatic fibrosis. 6. Induces oxidative stress.