NASH-non-alcoholic steatohepatitis, AMP-antimicrobial peptide, damage-associated molecular patterns, FXR-Farnesoid-X Receptor, GLP-1-glucagon-like peptide 1, IR-insulin resistance, LPS-lipopolysaccharide, NF-KB-nuclear factor kappa-B, NLR-nod-like receptors, PAMPS-pathogen‐associated molecular patterns, SCFA-short-chain fatty acids; TG-triglyceride; TLR-toll-like receptors, Treg-regulatory T cells; TMAO-trimethylamine N-oxide. The gene discussed is NR1H4; the disease is Insulin resistance.