PNPLA3 and metabolic dysfunction-associated steatohepatitis: The majority of data has been established for the PNPLA3 gene found in 15% of the general population, in which a mutation at position 148 is linked to 2.5-fold greater odds of the development of severe steatohepatitis, excessive, inflammation, injury and scarring; consequently, bearing higher risks of NASH, progression to cirrhosis and HCC [52].