The diagnostic yields within the subgroups among the included studies are as follows: Huang et al. revealed 69.2% for nephrolithiasis, 84.6% for nephrocalcinosis, and 83.3% for nephrolithiasis+nephrocalcinosis, while the mutated genes were CLCN5 and OCRL [8]. The gene discussed is OCRL; the disease is nephrolithiasis.