The most significant CpG (cg01601845; p = 1.53 × 10–6) was located in Open Sea in the gene-body of the IQSEC1 gene, gene linked to regulation of postsynaptic neurotransmitter receptor internalization (Kishore et al., 2020), as well as to treatment response in depression with citalopram in a prior GWAS (rs11128623) (Garriock et al., 2010). Here, IQSEC1 is linked to depressive disorder.