BDNF and major depressive disorder: Nonetheless, as depression and recovery from depression have been linked to improved neuronal connectivity (Dichter et al., 2015; Dunlop et al., 2019; Long et al., 2020), inflammation (Gasparini et al., 2022), and neurotrophic factors, such as the BDNF-pathway (Duman and Aghajanian, 2014; Li et al., 2021), we expect these signals to be represented in our pathway analysis.