However, as we begin to reclassify ADPKD into its genetic subtypes such as the work being performed by ClinGen [8], we can begin to understand ADPKD subtype by genotype, such as ADPKD-PKD1, ADPKD-PKD2, ADPKD-IFT140 etc. and define personalised approaches to this set of rare diseases. Here, PKD2 is linked to autosomal dominant polycystic kidney disease.