Positive correlations were observed between the glycolysis-lactate signature and the infiltration of tumor lymphocytes such as resting and activated dendritic cells, resting mast cells, memory resting CD4+ T cells and activated NK cells, while memory activated CD4+ T cells, plasma cells, CD8+ T cells, Macrophages M0 and naïve B cells were negatively correlated (Figure 6F). The gene discussed is CD8A; the disease is neoplasm.