One of the mechanisms by which glycolysis influences lung cancer is through its effect on hypoxia-inducible factor 1 (HIF-1), which is activated by low oxygen levels and high glycolytic activity in tumor cells, leading to increased expression of vascular endothelial growth factor (VEGF), matrix metalloproteinases (MMPs), and glucose transporters (GLUTs). This evidence concerns the gene HIF1A and lung cancer.