For example, EZH2 directly regulates CMYC expression via association with the estrogen receptor alpha (ERα) and β-catenin (52), and conversely, MYC binds the promoter of EZH2 and regulates its expression in prostate cancer cells (53) and B cell lymphomas (19). The gene discussed is EZH2; the disease is B-cell non-Hodgkin lymphoma.