In the context of low variant allele frequency in genes which are strongly correlated to clonal hematopoiesis (CH) like TET2 or DNMT3A it is difficult (if not impossible) to certainly attribute the mutation to the lymphoma cells; in this case, we normally add a comment highlighting this difficulty and recommending further studies (on peripheral blood or bone marrow). This evidence concerns the gene TET2 and cyclic hematopoiesis.