PTBP1 and colorectal carcinoma: Furthermore, multiple studies have suggested that PTBP1 (254), lncRNA SNHG6 (255), lncRNA HOXB-AS3 (256), Sam68 (257), MicroRNA-124 (258), LncRNA XIST/miR-137 axis (259), TRIM29 (260), and other molecules can target PKM1/PKM2 and influence their ratio, thereby impacting the growth, glycolysis, and even chemoresistance of CRC cells.