IL6R and neoplasm: IL-6 can bind to IL-6R or sIL6-R to form the IL-6/IL-6R complex which can interact with the IL-6 transducer expressed gp130, subsequently results in gp130 dimerization and phosphorylation and activates the receptor-associated kinases such as JAK1, JAK2, and Tyk2, which eventually promote the cell proliferation and tumor progression (230).