Furthermore, their study also found that CHERP and SR140, both identified as U2 snRNP-associated proteins, can regulate the splicing of UPF3A pre-mRNA by binding to the enhancer elements in exon 4 of UPF3A and activating its inclusion, thereby affecting the proliferation of CRC cells (112). The gene discussed is UPF3A; the disease is colorectal carcinoma.