PLK1 and posterior cortical atrophy: In vitro cell experiments have confirmed that upregulation of PLK1 expression can induce epithelial-mesenchymal transformation of prostate epithelial cells, increasing their migration ability and malignant transformation potential (61); animal experiments have found a significant increase in PLK1 expression in PCa xenograft animal models with castration resistance, suggesting that PLK1 may promote disease progression in PCa (63).