KLK3 and posterior cortical atrophy: Previous studies have shown that the AUC and C-index of PSA for predicting the risk of biochemical recurrence in PCa patients are both less than 0.75, and the AUC of Gleason score is only 0.715 (10, 11).Therefore, the identification and construction of a more accurate and specific risk signature is of great importance to guide the diagnosis, treatment and follow-up of PCa patients.