E2F1 and Familial prostate cancer: Although we did not detect a direct interaction between EHMT1 and E2F1 in our experiments, a previous study from us revealed the important role of LSD1 in stabilizing E2F1 chromatin binding in prostate cancer cells, and a strong interaction between LSD1 and E2F1 was observed (ref. 37; also see Fig. 7C).