TSPO and Alzheimer disease: This hypothesis is supportedby a previous study showing that the TSPO knockout leads to an increasein glucose consumption.25 Supporting theidea of a role for TSPO in glucose metabolism, PK11195 was shown toregulate glucose pathways in mice and zebrafish.61,62 It could therefore be hypothesized that the increase in TPSO isrelated to hypometabolism observed in AD patients.