In fact, in an experimentalautoimmune encephalomyelitis model of multiple sclerosis, the dynamicsof TSPO overexpression indicated an involvement of microglia and thenof astrocytes, during the remyelination phase.10 In Alzheimer’s disease, the overexpression of TSPOin astrocytes occurs before the one in microglia.11 Thus, understanding the role of TSPO according to its cellularorigin would allow better targeting of TSPO-based therapies. Here, TSPO is linked to early-onset autosomal dominant Alzheimer disease.