Conversely, downregulation of miR-383 by TMPO-AS1 in lung adenocarcinoma and pancreatic carcinoma and MIR4435-2HG in head and neck squamous cell carcinoma led to tumor progression (Mu et al., 2020; Wang et al., 2021; Xue et al., 2021). The gene discussed is TMPO; the disease is neoplasm.