It was interesting that body mass index (BMI) (Speliotes et al., 2010), obesity (Berndt et al., 2013; Speliotes et al., 2010) high-density lipoprotein (HDL) cholesterol levels (Teslovich et al., 2010; Waterworth et al., 2010; Willer et al., 2013) were correlated with rs13107325 SNP (results in Ala-Thr amino acid change at position 391 of the protein) of the Solute Carrier Family 39 Member 8 (SLC39A8) gene in several genome-wide association studies (GWAS). The gene discussed is SLC39A8; the disease is obesity due to melanocortin 4 receptor deficiency.