As shown in Fig. 3A, The SLC39A8-correlated genes were enriched in “Cholesterol Metabolism With Bloch and Kandutschrussell pathways”, “Cholesterol Biosynthesis Pathway”, “Cholesterol Synthesis Disorders”, “Nrf2 pathway” and “Mevalonate Arm of Cholesterol Biosynthesis Pathway” in WikiPathways based on normalized enrichment score (NES). Here, SLC39A8 is linked to cholesterol biosynthetic process disease.