METTL3 and acute myeloid leukemia: Regarding the expression of 20 genes related to m6A RNA methylation, we found that the expression significantly differs between the AML and control groups (Fig. 1A); these genes included five downregulated genes (METTL14, WTAP, HNRNPC, KIAA1429, FTO, and WTAP) and 15 upregulated genes (IGF2BP1, IGF2BP3, YTHDF1, YTHDF2, YTHDF3, ALKBH5, METTL3, RBM15, RBM15B, YTHDC1, YTHDC2, IGF2BP2, ZC3H13, HNRNPA2B1, and RBMX) (Fig. 1B).