CD274 and cancer: As shown in Fig. 1A, PD-L1 showed the highest expression in the border regions (48.53%), followed by paracancer stroma (40.00%), and cancer nest (12.68%), while A2BR showed the highest expression in the cancer nest (34.25%), followed by border (19.72%), and paracancer stroma (3.23%; Figs. 1B and 1C).