After twelve weeks, the total quiescent time in the CON was greater than that in the CON+CS group, and the mice in the CON+CS and HF+Apoe-/-+CS groups entered the central area less frequently than those in the CON and HF+Apoe-/- groups, and the former also had a shorter duration in the centrals and a corresponding increase in quiescent time in the non-central area (Fig. 2D). The gene discussed is APOE; the disease is hydrops fetalis.