Several compounds or extracts from natural products, such as darmmarane sapogenins originating from ginseng (Jiang et al., 2020), tannins from Terminalia chebula fruits (Chandrasekhar et al., 2018), and diterpene quinone Tanshinone IIA isolated from the roots of Salvia miltiorrhiza Bunge (Jiang et al., 2022), attenuate anxiety by activating the CREB/BDNF pathways. The gene discussed is CREB1; the disease is Anxiety.