In addition, the upregulation of AlkB homolog 5 (ALKBH5) promotes the upregulation of MAP3K8 expression in tumor cells, which induces the phosphorylation of the c-Jun N-terminal kinase (JNK)/extracellular signal-regulated kinase (ERK) pathway, resulting in the upregulation of IL-8 expression. The gene discussed is CXCL8; the disease is neoplasm.