Scopolin regulated glycolysis-related proteins glucose-6-phosphate isomerase (GPI), glycerol-3-phosphate dehydrogenase, mitochondrial (GPD2) and phosphoglycerate kinase 2 (PGK2) expression and inhibited protein-protein interaction, reduced energy metabolism in liver cancer tissue, inhibiting tumor growth (Wang et al., 2022a). The gene discussed is PGK2; the disease is neoplasm.