In Melanoma A375 and A875 cells (Guo et al., 2016), Naringin inhibits the phosphorylation of non Receptor tyrosine kinase c-Src, downregulates the expression of Bcl2, upregulates the expression of caspase-3 and Bax, and exerts apoptosis inducing activity by blocking the c-Src/AKT signaling pathway; In lung cancer H1299 cells (Xuemei et al., 2018), Naringin also plays a role in promoting apoptosis by regulating AKT signaling pathway, reducing Bcl2, and increasing caspase-3 and Bax levels. This evidence concerns the gene CASP3 and melanoma.