BCL2 and neoplasm: In summary, Naringin induced apoptosis in tumor cells mainly by regulating the Caspase family (Caspase-1, -3, -7, -8, -9, etc.)and Bcl-2 family (Bcl-2, Bcl-xL, Bax, Bad, etc.), and its mechanism of action was related to the regulation of 3 basic pathways (mitochondria, endoplasmic reticulum, death receptors), inhibition of JAK/STAT pathway, Akt related pathway, CHOP related pathway, regulation of microRNAs (miR-216a, miR-628-5p), and regulation of the expression of apoptosis-related factors and proteins (survivin, P53, Fas, COX-2, CytC, etc.).