In conclusion, Naringin mainly inhibits the signaling pathways such as Akt/NF-κB by down-regulating the expression of drug resistance gene MDR mRNA and related proteins P-gp and MRP, thus reversing the resistance of tumor cells to chemotherapeutic drugs, and its combination with chemotherapeutic drugs can significantly enhance the sensitivity of cancer cells to the drugs. The gene discussed is NFKB1; the disease is neoplasm.