STAT3 and esophageal cancer: Feng et al. (Feng et al., 2021) observed a significant decrease in p-STAT3/STAT3 and p-JAK2/JAK2 ratio after Naringin was applied to esophageal cancer Eca109 cells, suggesting that Naringin blocked the activation of protein Tyrosine kinase signal transducer/activator of transcription (JAK/STAT) signal pathway, thereby inhibiting the proliferation and colony formation of esophageal cancer cells.