Albayrak, Weili and others found that Naringin can induce reactive oxygen species (ROS) mediated Endoplasmic reticulum stress and activate PERK/eIF2 α/The ATF4/CHOP axis upregulates Bax and downregulates the level of B-lymphomatoma-2 gene (Bcl-2), thereby promoting apoptosis in colon cancer HT29 cells (Albayrak et al., 2021) and thyroid cancer B-CPAP cells (Li et al., 2022). This evidence concerns the gene ATF4 and thyroid cancer.