The research of Guo and Wang Wei et al. shows that Naringin can significantly reduce the expression of its downstream signal MMP2 and MMP9, and inhibit the migration and invasion potential of Melanoma A375 cells and glioma U87 by inhibiting the phosphorylation of c-Src (Guo et al., 2016) and inhibiting the PI3K/AKT pathway (Wei et al., 2020), respectively. Here, AKT1 is linked to melanoma.