ATF4 and thyroid gland carcinoma: In addition, in thyroid cancer B-CPAP cells, Naringin regulates PERK/eIF2 α/ATF4/CHOP axis can upregulate the expression of E-cadherin and downregulate the expression of N-cadherin and Vimentin, which can significantly inhibit tumor cell metastasis and invasion (Li et al., 2022).