CDK4 and cervical cancer: In the study of gastric cancer SNU-1 (Xu et al., 2021) cells and Cervical cancer C33A, SiHA, HeLa cells (Lin et al., 2020), Naringin blocked PI3K/AKT pathway and β- Catenin/GSK-3 β Pathways to reduce the expression of cell cycle survival proteins c-Myc, CDK2, CDK4, and Cyclin D1, and increase the expression of p21/cip1 and p27/kip1.