It is reported that (Liqiong and Na, 2020), Naringin inhibits cyclinD1 in colon cancer SW620 cells by up regulating the expression of tumor suppressor gene ARHI and p21 protein; Naringin inhibits the expression of Cyclin D1 in Osteosarcoma cells MG63 and U2OS by down regulating the transcription inhibitor Zeb1 (Ming et al., 2018), which blocks the G1 phase cell cycle to a certain extent, thus improving the inhibition rate of tumor cell proliferation (Yi et al., 2018). The gene discussed is DIRAS3; the disease is malignant colon neoplasm.