PGP and neoplasm: According to Zhu et al. (2020), Naringin partially reversed the expression of platinum drugs such as cisplatin in ovarian cancer SKOV3/CDDP cells by down-regulating the expression of P-gp protein, epoxygenase-2 (COX-2), down-regulating the expression of drug resistance genes MDR1 mRNA, MRP2 mRNA, and MRP2 protein, reducing intra-tumor cellular chemotherapeutic drug efflux, and increasing drug concentration The reversal mechanism was related to the blockade of NF-κB signaling pathway.