observed cytoplasmic vesicle and autophagosome formation in naringenin-treated AGS cells and found that naringenin-induced autophagy in gastric cancer AGS cells by activating the MAPK pathway, downregulating the cascade, and upregulating the autophagy proteins Beclin-1 and LC3B and phosphorylated mitogen-activated protein kinases (MAPKs). Here, MAP1LC3B is linked to gastric cancer.