AKT1 and neoplasm: To sum up, Naringin mainly inhibits PI3K/AKT/mTOR, NF kB, Wnt/β-catenin signaling pathways such as catenin, JAK/STAT, RAS/RAf/ERK, JNK/p38 MAPK, as well as endogenous non coding single stranded small RNAs (miRNAs), regulate the expression of cell cycle related factors and proteins such as Cyclin D1/E, CDKs, c-Myc, and c-Src, thereby inducing cell cycle arrest at multiple stages, with the G0/G1 phase being the most common, thereby inhibiting tumor cell proliferation).