[Actinidiaceae] (10 ml per day) for nine months, and combined with exercise (each patient walks about 1.5 to 2 miles per day), improves anti-oxidative and anti-inflammatory status of T2DM patients by activating Kelch-like ECH-associated protein 1 (Keap1) and nuclear factor erythroid-derived 2-like 2 (Nrf2) via increasing microRNA-424 (Sun et al., 2017). Here, NFE2L2 is linked to type 2 diabetes mellitus.